Artistic interest in Anatomy during the late fifteenth and early sixteenth centuries was so advanced that artists often surpassed and advanced medical research. This flayed figure of a horse is thought to have come from the studio of Giambologna (1529 - 1608), the most influential sculptor in Europe after Michelangelo (1475 - 1564). It is likely that the original modelling would have been in wax, which could be coloured to provide greater anatomical detail, and used as a study model. A small number of bronze sculptures were then cast in Giambologna�s studio, with one acquired by the University of Edinburgh Art Collection in the 1830s.It has been argued that this work was made directly from drawings by Leonardo da Vinci (1452 - 1519), who created numerous studies on the anatomy of horses. A distinct visual relationship also extends to the Ruini woodcut, on display here, suggesting that the sculpture directly informed the illustration.